evaluation of anthracycline effects on nt-probnp plasma level in children with malignancy

background: nt-probnp is a marker that is released from ventricles in response to pressure and volume overload. raised plasma level of nt-probnp is seen in ventricular dysfunction, ventricular muscular mass reduction or ventricular ischemia. anthracyclines are widely used in treatment of pediatric cancer but their use is associated with cardiotoxicity which increases mortality and morbidity. we measured the plasma levels of nt-probnp to determine whether it might serve as a simple prognostic indicator of anthracycline-induced cardiotoxicity and to estimate the toxic levels of anthracyclines in children with malignancy treated with anthracycline containing regimens in tehran